The irreversible change of the cornea and conjunctiva might occur by insufficient removal of coarse residues (e.g. mortar, lime, etc.). In this case, it is the loss of transparency – affecting or causing transparency of cornea, conjunctival scarring, palpebral adhesion and bulbar conjunctiva adhesion.
When applying a contact lens, eicosanoids are produced in the epithelium which have the ability to induce swelling of the endothelial cells and stroma of the cornea. Repeated exposure of endothelial cells by eicosanoids leads to the reconstruction of cells and ultimately leads to irreversible changes of the cornea.